Rho GTPase–independent regulation of mitotic progression by the RhoGEF Net1

Mechanisms accounting for the role of Net1 in cell proliferation have not been described. This study shows that Net1 plays a Rho GTPase–independent role in controlling mitotic spindle assembly and kinetochore attachment and is required for centrosome activation of Pak2 and Aurora A.

Bibliographic Details
Main Authors: Menon, Sarita, Oh, Wonkyung, Carr, Heather S., Frost, Jeffrey A.
Format: Online
Language:English
Published: The American Society for Cell Biology 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756918/