FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System
The Drosophila compound eye is a large sensory organ that places a high demand on oxygen supplied by the tracheal system. Although the development and function of the Drosophila visual system has been extensively studied, the development and contribution of its tracheal system has not been syste...
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| Format: | Online |
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Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753266/ |
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pubmed-37532662013-08-29 FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System Chu, Wei-Chen Lee, Yuan-Ming Henry Sun, Yi Research Article The Drosophila compound eye is a large sensory organ that places a high demand on oxygen supplied by the tracheal system. Although the development and function of the Drosophila visual system has been extensively studied, the development and contribution of its tracheal system has not been systematically examined. To address this issue, we studied the tracheal patterns and developmental process in the Drosophila visual system. We found that the retinal tracheae are derived from air sacs in the head, and the ingrowth of retinal trachea begin at mid-pupal stage. The tracheal development has three stages. First, the air sacs form near the optic lobe in 42-47% of pupal development (pd). Second, in 47-52% pd, air sacs extend branches along the base of the retina following a posterior-to-anterior direction and further form the tracheal network under the fenestrated membrane (TNUFM). Third, the TNUFM extend fine branches into the retina following a proximal-to-distal direction after 60% pd. Furthermore, we found that the trachea extension in both retina and TNUFM are dependent on the FGF(Bnl)/FGFR(Btl) signaling. Our results also provided strong evidence that the photoreceptors are the source of the Bnl ligand to guide the trachea ingrowth. Our work is the first systematic study of the tracheal development in the visual system, and also the first study demonstrating the interactions of two well-studied systems: the eye and trachea. Public Library of Science 2013-08-26 /pmc/articles/PMC3753266/ /pubmed/23991208 http://dx.doi.org/10.1371/journal.pone.0073878 Text en © 2013 Chu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chu, Wei-Chen Lee, Yuan-Ming Henry Sun, Yi |
| spellingShingle |
Chu, Wei-Chen Lee, Yuan-Ming Henry Sun, Yi FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System |
| author_facet |
Chu, Wei-Chen Lee, Yuan-Ming Henry Sun, Yi |
| author_sort |
Chu, Wei-Chen |
| title |
FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System |
| title_short |
FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System |
| title_full |
FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System |
| title_fullStr |
FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System |
| title_full_unstemmed |
FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System |
| title_sort |
fgf /fgfr signal induces trachea extension in the drosophila visual system |
| description |
The
Drosophila
compound eye is a large sensory organ that places a high demand on oxygen supplied by the tracheal system. Although the development and function of the
Drosophila
visual system has been extensively studied, the development and contribution of its tracheal system has not been systematically examined. To address this issue, we studied the tracheal patterns and developmental process in the
Drosophila
visual system. We found that the retinal tracheae are derived from air sacs in the head, and the ingrowth of retinal trachea begin at mid-pupal stage. The tracheal development has three stages. First, the air sacs form near the optic lobe in 42-47% of pupal development (pd). Second, in 47-52% pd, air sacs extend branches along the base of the retina following a posterior-to-anterior direction and further form the tracheal network under the fenestrated membrane (TNUFM). Third, the TNUFM extend fine branches into the retina following a proximal-to-distal direction after 60% pd. Furthermore, we found that the trachea extension in both retina and TNUFM are dependent on the FGF(Bnl)/FGFR(Btl) signaling. Our results also provided strong evidence that the photoreceptors are the source of the Bnl ligand to guide the trachea ingrowth. Our work is the first systematic study of the tracheal development in the visual system, and also the first study demonstrating the interactions of two well-studied systems: the eye and trachea. |
| publisher |
Public Library of Science |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753266/ |
| _version_ |
1612006013032988672 |