Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting

We have utilized the persistent elevation of fractional excretion (FE) of urate, > 10%, to differentiate cerebral/renal salt wasting (RSW) from the syndrome of inappropriate antidiuretic hormone secretion (SIADH), in which a normalization of FEurate occurs after correction of hyponatremia. Previ...

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Main Authors:	Youmans, Steven J, Fein, Miriam R, Wirkowski, Elizabeth, Maesaka, John K
Format:	Online
Language:	English
Published:	F1000Research 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752684/

id	pubmed-3752684
recordtype	oai_dc
spelling	pubmed-37526842013-12-05 Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting Youmans, Steven J Fein, Miriam R Wirkowski, Elizabeth Maesaka, John K Research Article We have utilized the persistent elevation of fractional excretion (FE) of urate, > 10%, to differentiate cerebral/renal salt wasting (RSW) from the syndrome of inappropriate antidiuretic hormone secretion (SIADH), in which a normalization of FEurate occurs after correction of hyponatremia. Previous studies suggest as well that an elevated FEurate with normonatremia, without pre-existing hyponatremia, is also consistent with RSW, including studies demonstrating induction of RSW in rats infused with plasma from normonatremic neurosurgical and Alzheimer’s disease patients. The present studies were designed to test whether precipitates from the urine of normonatremic neurosurgical patients, with either normal or elevated FEurate, and patients with SIADH, display natriuretic activity. F1000Research 2013-06-13 /pmc/articles/PMC3752684/ /pubmed/24358843 http://dx.doi.org/10.12688/f1000research.2-126.v2 Text en Copyright: © 2013 Youmans SJ et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Youmans, Steven J Fein, Miriam R Wirkowski, Elizabeth Maesaka, John K
spellingShingle	Youmans, Steven J Fein, Miriam R Wirkowski, Elizabeth Maesaka, John K Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
author_facet	Youmans, Steven J Fein, Miriam R Wirkowski, Elizabeth Maesaka, John K
author_sort	Youmans, Steven J
title	Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
title_short	Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
title_full	Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
title_fullStr	Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
title_full_unstemmed	Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
title_sort	demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting
description	We have utilized the persistent elevation of fractional excretion (FE) of urate, > 10%, to differentiate cerebral/renal salt wasting (RSW) from the syndrome of inappropriate antidiuretic hormone secretion (SIADH), in which a normalization of FEurate occurs after correction of hyponatremia. Previous studies suggest as well that an elevated FEurate with normonatremia, without pre-existing hyponatremia, is also consistent with RSW, including studies demonstrating induction of RSW in rats infused with plasma from normonatremic neurosurgical and Alzheimer’s disease patients. The present studies were designed to test whether precipitates from the urine of normonatremic neurosurgical patients, with either normal or elevated FEurate, and patients with SIADH, display natriuretic activity.
publisher	F1000Research
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752684/
_version_	1612005889072431104

Demonstration of natriuretic activity in urine of neurosurgical patients with renal salt wasting

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