Effects of multimerization on the temporal variability of protein complex abundance

We explore whether the process of multimerization can be used as a means to regulate noise in the abundance of functional protein complexes. Additionally, we analyze how this process affects the mean level of these functional units, response time of a gene, and temporal correlation between the numbe...

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Main Authors:	Häkkinen, Antti, Tran, Huy, Yli-Harja, Olli, Ingalls, Brian, Ribeiro, Andre S
Format:	Online
Language:	English
Published:	BioMed Central 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750523/

id	pubmed-3750523
recordtype	oai_dc
spelling	pubmed-37505232013-08-27 Effects of multimerization on the temporal variability of protein complex abundance Häkkinen, Antti Tran, Huy Yli-Harja, Olli Ingalls, Brian Ribeiro, Andre S Research We explore whether the process of multimerization can be used as a means to regulate noise in the abundance of functional protein complexes. Additionally, we analyze how this process affects the mean level of these functional units, response time of a gene, and temporal correlation between the numbers of expressed proteins and of the functional multimers. We show that, although multimerization increases noise by reducing the mean number of functional complexes it can reduce noise in comparison with a monomer, when abundance of the functional proteins are comparable. Alternatively, reduction in noise occurs if both monomeric and multimeric forms of the protein are functional. Moreover, we find that multimerization either increases the response time to external signals or decreases the correlation between number of functional complexes and protein production kinetics. Finally, we show that the results are in agreement with recent genome-wide assessments of cell-to-cell variability in protein numbers and of multimerization in essential and non-essential genes in Escherichia coli, and that the effects of multimerization are tangible at the level of genetic circuits. BioMed Central 2013-08-12 /pmc/articles/PMC3750523/ /pubmed/24267954 http://dx.doi.org/10.1186/1752-0509-7-S1-S3 Text en Copyright © 2013 Häkkinen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Häkkinen, Antti Tran, Huy Yli-Harja, Olli Ingalls, Brian Ribeiro, Andre S
spellingShingle	Häkkinen, Antti Tran, Huy Yli-Harja, Olli Ingalls, Brian Ribeiro, Andre S Effects of multimerization on the temporal variability of protein complex abundance
author_facet	Häkkinen, Antti Tran, Huy Yli-Harja, Olli Ingalls, Brian Ribeiro, Andre S
author_sort	Häkkinen, Antti
title	Effects of multimerization on the temporal variability of protein complex abundance
title_short	Effects of multimerization on the temporal variability of protein complex abundance
title_full	Effects of multimerization on the temporal variability of protein complex abundance
title_fullStr	Effects of multimerization on the temporal variability of protein complex abundance
title_full_unstemmed	Effects of multimerization on the temporal variability of protein complex abundance
title_sort	effects of multimerization on the temporal variability of protein complex abundance
description	We explore whether the process of multimerization can be used as a means to regulate noise in the abundance of functional protein complexes. Additionally, we analyze how this process affects the mean level of these functional units, response time of a gene, and temporal correlation between the numbers of expressed proteins and of the functional multimers. We show that, although multimerization increases noise by reducing the mean number of functional complexes it can reduce noise in comparison with a monomer, when abundance of the functional proteins are comparable. Alternatively, reduction in noise occurs if both monomeric and multimeric forms of the protein are functional. Moreover, we find that multimerization either increases the response time to external signals or decreases the correlation between number of functional complexes and protein production kinetics. Finally, we show that the results are in agreement with recent genome-wide assessments of cell-to-cell variability in protein numbers and of multimerization in essential and non-essential genes in Escherichia coli, and that the effects of multimerization are tangible at the level of genetic circuits.
publisher	BioMed Central
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750523/
_version_	1612005135572008960

Effects of multimerization on the temporal variability of protein complex abundance

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