Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can int...

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Bibliographic Details
Main Authors: Linossi, Edmond M., Chandrashekaran, Indu R., Kolesnik, Tatiana B., Murphy, James M., Webb, Andrew I., Willson, Tracy A., Kedzierski, Lukasz, Bullock, Alex N., Babon, Jeffrey J., Norton, Raymond S., Nicola, Nicos A., Nicholson, Sandra E.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749136/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749136/

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