Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours
High levels of lactate and H+-ions play an important role in the invasive and metastatic cascade of some tumours. We develop a mathematical model of cellular pH regulation focusing on the activity of the Na+/H+ exchanger (NHE) and the lactate/H+ symporter (MCT) to investigate the spatial correlation...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749110/ |