Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation

The cerebellum refines the accuracy and timing of motor performance. How it encodes information to perform these functions is a major topic of interest. We performed whole cell and extracellular recordings of Purkinje cells (PCs) and cerebellar nuclei neurons (CNs) in vivo, while activating PCs with...

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Main Authors:	Witter, Laurens, Canto, Cathrin B., Hoogland, Tycho M., de Gruijl, Jornt R., De Zeeuw, Chris I.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748751/

id	pubmed-3748751
recordtype	oai_dc
spelling	pubmed-37487512013-08-22 Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation Witter, Laurens Canto, Cathrin B. Hoogland, Tycho M. de Gruijl, Jornt R. De Zeeuw, Chris I. Neuroscience The cerebellum refines the accuracy and timing of motor performance. How it encodes information to perform these functions is a major topic of interest. We performed whole cell and extracellular recordings of Purkinje cells (PCs) and cerebellar nuclei neurons (CNs) in vivo, while activating PCs with light in transgenic mice. We show for the first time that graded activation of PCs translates into proportional CN inhibition and induces rebound activity in CNs, which is followed by graded motor contractions timed to the cessation of the stimulus. Moreover, activation of PC ensembles led to disinhibition of climbing fiber activity, which coincided with rebound activity in CNs. Our data indicate that cessation of concerted activity in ensembles of PCs can regulate both timing and strength of movements via control of rebound activity in CNs. Frontiers Media S.A. 2013-08-21 /pmc/articles/PMC3748751/ /pubmed/23970855 http://dx.doi.org/10.3389/fncir.2013.00133 Text en Copyright © 2013 Witter, Canto, Hoogland, de Gruijl and De Zeeuw. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Witter, Laurens Canto, Cathrin B. Hoogland, Tycho M. de Gruijl, Jornt R. De Zeeuw, Chris I.
spellingShingle	Witter, Laurens Canto, Cathrin B. Hoogland, Tycho M. de Gruijl, Jornt R. De Zeeuw, Chris I. Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation
author_facet	Witter, Laurens Canto, Cathrin B. Hoogland, Tycho M. de Gruijl, Jornt R. De Zeeuw, Chris I.
author_sort	Witter, Laurens
title	Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation
title_short	Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation
title_full	Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation
title_fullStr	Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation
title_full_unstemmed	Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation
title_sort	strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after purkinje cell activation
description	The cerebellum refines the accuracy and timing of motor performance. How it encodes information to perform these functions is a major topic of interest. We performed whole cell and extracellular recordings of Purkinje cells (PCs) and cerebellar nuclei neurons (CNs) in vivo, while activating PCs with light in transgenic mice. We show for the first time that graded activation of PCs translates into proportional CN inhibition and induces rebound activity in CNs, which is followed by graded motor contractions timed to the cessation of the stimulus. Moreover, activation of PC ensembles led to disinhibition of climbing fiber activity, which coincided with rebound activity in CNs. Our data indicate that cessation of concerted activity in ensembles of PCs can regulate both timing and strength of movements via control of rebound activity in CNs.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748751/
_version_	1612004591652569088

Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation

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