Crosstalk of Arf and Rab GTPases en route to cilia
Small GTPases are versatile temporal and spatial regulators of virtually all cellular processes including signal transduction, cytoskeleton dynamics and membrane trafficking. They function as molecular switches, aided by a multitude of regulatory and effector proteins that link them into functional...
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| Format: | Online |
| Language: | English |
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Landes Bioscience
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747259/ |
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pubmed-3747259 |
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pubmed-37472592013-08-27 Crosstalk of Arf and Rab GTPases en route to cilia Deretic, Dusanka Mini Review Small GTPases are versatile temporal and spatial regulators of virtually all cellular processes including signal transduction, cytoskeleton dynamics and membrane trafficking. They function as molecular switches, aided by a multitude of regulatory and effector proteins that link them into functional networks. A picture is beginning to emerge whereupon scaffold proteins with many functional domains perform the regulatory and effector functions, thus allowing the ordered recruitment and activation of small GTPases. This leads to the formation of scaffolding patches that coordinate cargo concentration and capture, with the recruitment and activation of the membrane tethering complexes and fusion regulators. This review will focus on the crosstalk of Arf and Rab GTPases at the Golgi complex and the scaffolds that facilitate their activation during trafficking of sensory receptors to primary cilia. The evolutionary conservation of the GTPase cascades in ciliogenesis and yeast budding will be discussed. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3747259/ /pubmed/23567335 http://dx.doi.org/10.4161/sgtp.24396 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Deretic, Dusanka |
| spellingShingle |
Deretic, Dusanka Crosstalk of Arf and Rab GTPases en route to cilia |
| author_facet |
Deretic, Dusanka |
| author_sort |
Deretic, Dusanka |
| title |
Crosstalk of Arf and Rab GTPases en route to cilia |
| title_short |
Crosstalk of Arf and Rab GTPases en route to cilia |
| title_full |
Crosstalk of Arf and Rab GTPases en route to cilia |
| title_fullStr |
Crosstalk of Arf and Rab GTPases en route to cilia |
| title_full_unstemmed |
Crosstalk of Arf and Rab GTPases en route to cilia |
| title_sort |
crosstalk of arf and rab gtpases en route to cilia |
| description |
Small GTPases are versatile temporal and spatial regulators of virtually all cellular processes including signal transduction, cytoskeleton dynamics and membrane trafficking. They function as molecular switches, aided by a multitude of regulatory and effector proteins that link them into functional networks. A picture is beginning to emerge whereupon scaffold proteins with many functional domains perform the regulatory and effector functions, thus allowing the ordered recruitment and activation of small GTPases. This leads to the formation of scaffolding patches that coordinate cargo concentration and capture, with the recruitment and activation of the membrane tethering complexes and fusion regulators. This review will focus on the crosstalk of Arf and Rab GTPases at the Golgi complex and the scaffolds that facilitate their activation during trafficking of sensory receptors to primary cilia. The evolutionary conservation of the GTPase cascades in ciliogenesis and yeast budding will be discussed. |
| publisher |
Landes Bioscience |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747259/ |
| _version_ |
1612004069895831552 |