Hypoxia-Inducible Factor-1α and Interleukin 33 Form a Regulatory Circuit to Perpetuate the Inflammation in Rheumatoid Arthritis

Hypoxia-Inducible Factor-1α and Interleukin 33 Form a Regulatory Circuit to Perpetuate the Inflammation in Rheumatoid Arthritis

Hyperplasia of synovial fibroblasts, infiltration with inflammatory cytokines, and tissue hypoxia are the major characteristics of rheumatoid arthritis (RA). Interleukin 33 (IL-33) is a newly identified inflammatory cytokine exacerbating the disease severity of RA. Hypoxia-inducible factor-1α (HIF-1...

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Bibliographic Details
Main Authors: Hu, Fanlei, Shi, Lianjie, Mu, Rong, Zhu, Jiaxin, Li, Yingni, Ma, Xiaoxu, Li, Chun, Jia, Rulin, Yang, Dongyue, Li, Yun, Li, Zhanguo
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744448/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744448/

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