Ionizing radiation, ion transports, and radioresistance of cancer cells

The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds t...

Full description

Bibliographic Details
Main Authors:	Huber, Stephan M., Butz, Lena, Stegen, Benjamin, Klumpp, Dominik, Braun, Norbert, Ruth, Peter, Eckert, Franziska
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743404/

id	pubmed-3743404
recordtype	oai_dc
spelling	pubmed-37434042013-08-21 Ionizing radiation, ion transports, and radioresistance of cancer cells Huber, Stephan M. Butz, Lena Stegen, Benjamin Klumpp, Dominik Braun, Norbert Ruth, Peter Eckert, Franziska Physiology The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds the DNA repair capacity of the tumor cell. Ionizing radiation reportedly does not only act on the DNA in the nucleus but also on the plasma membrane. In particular, ionizing radiation-induced modifications of ion channels and transporters have been reported. Importantly, these altered transports seem to contribute to the survival of the irradiated tumor cells. The present review article summarizes our current knowledge on the underlying mechanisms and introduces strategies to radiosensitize tumor cells by targeting plasma membrane ion transports. Frontiers Media S.A. 2013-08-14 /pmc/articles/PMC3743404/ /pubmed/23966948 http://dx.doi.org/10.3389/fphys.2013.00212 Text en Copyright © 2013 Huber, Butz, Stegen, Klumpp, Braun, Ruth and Eckert. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Huber, Stephan M. Butz, Lena Stegen, Benjamin Klumpp, Dominik Braun, Norbert Ruth, Peter Eckert, Franziska
spellingShingle	Huber, Stephan M. Butz, Lena Stegen, Benjamin Klumpp, Dominik Braun, Norbert Ruth, Peter Eckert, Franziska Ionizing radiation, ion transports, and radioresistance of cancer cells
author_facet	Huber, Stephan M. Butz, Lena Stegen, Benjamin Klumpp, Dominik Braun, Norbert Ruth, Peter Eckert, Franziska
author_sort	Huber, Stephan M.
title	Ionizing radiation, ion transports, and radioresistance of cancer cells
title_short	Ionizing radiation, ion transports, and radioresistance of cancer cells
title_full	Ionizing radiation, ion transports, and radioresistance of cancer cells
title_fullStr	Ionizing radiation, ion transports, and radioresistance of cancer cells
title_full_unstemmed	Ionizing radiation, ion transports, and radioresistance of cancer cells
title_sort	ionizing radiation, ion transports, and radioresistance of cancer cells
description	The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds the DNA repair capacity of the tumor cell. Ionizing radiation reportedly does not only act on the DNA in the nucleus but also on the plasma membrane. In particular, ionizing radiation-induced modifications of ion channels and transporters have been reported. Importantly, these altered transports seem to contribute to the survival of the irradiated tumor cells. The present review article summarizes our current knowledge on the underlying mechanisms and introduces strategies to radiosensitize tumor cells by targeting plasma membrane ion transports.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743404/
_version_	1612003120320086016

Ionizing radiation, ion transports, and radioresistance of cancer cells

Similar Items