Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer

Pancreatic cancer (PC) remains a devastating disease with a five-year survival rate of <5%. The difficulty in making an early diagnosis and the frequent occurrence of metastasis are important reasons for this poor prognosis. In China, the incidence of PC has been increasing steadily. Therefore, t...

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Main Authors:	CHEN, JIONG, WU, WEN, ZHEN, CHUNSHENG, ZHOU, HANGCHEN, YANG, RENBAO, CHEN, LONGJIANG, HU, LIWEI
Format:	Online
Language:	English
Published:	D.A. Spandidos 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742809/

id	pubmed-3742809
recordtype	oai_dc
spelling	pubmed-37428092013-08-14 Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer CHEN, JIONG WU, WEN ZHEN, CHUNSHENG ZHOU, HANGCHEN YANG, RENBAO CHEN, LONGJIANG HU, LIWEI Articles Pancreatic cancer (PC) remains a devastating disease with a five-year survival rate of <5%. The difficulty in making an early diagnosis and the frequent occurrence of metastasis are important reasons for this poor prognosis. In China, the incidence of PC has been increasing steadily. Therefore, the present study aimed to identify effective markers in the early and advanced stages of PC. The expression levels of complement C3, complement C4b1 and apolipoprotein E (ApoE) in the various stages of PC were assessed by immunohistochemistry, RT-PCR and western blotting. Additionally, the statistical significance of the results was analyzed. The expression levels of complement C3, complement C4b1 and apoE were higher in PC compared with normal pancreatic tissues. No correlations were observed between complement C3 and tumor TNM staging or lymph node metastasis. However, complement C4b1 and apoE were markedly correlated with tumor TNM staging and lymph node metastasis. Complement C3 may be used as a marker for the diagnosis of early-stage PC, while complement C4b1 and apoE are closely correlated with tumor development, reflecting the biological behavior of PC, and thus may be used as diagnostic markers of advanced PC. D.A. Spandidos 2013-07 2013-04-30 /pmc/articles/PMC3742809/ /pubmed/23946775 http://dx.doi.org/10.3892/ol.2013.1326 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	CHEN, JIONG WU, WEN ZHEN, CHUNSHENG ZHOU, HANGCHEN YANG, RENBAO CHEN, LONGJIANG HU, LIWEI
spellingShingle	CHEN, JIONG WU, WEN ZHEN, CHUNSHENG ZHOU, HANGCHEN YANG, RENBAO CHEN, LONGJIANG HU, LIWEI Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer
author_facet	CHEN, JIONG WU, WEN ZHEN, CHUNSHENG ZHOU, HANGCHEN YANG, RENBAO CHEN, LONGJIANG HU, LIWEI
author_sort	CHEN, JIONG
title	Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer
title_short	Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer
title_full	Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer
title_fullStr	Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer
title_full_unstemmed	Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer
title_sort	expression and clinical significance of complement c3, complement c4b1 and apolipoprotein e in pancreatic cancer
description	Pancreatic cancer (PC) remains a devastating disease with a five-year survival rate of <5%. The difficulty in making an early diagnosis and the frequent occurrence of metastasis are important reasons for this poor prognosis. In China, the incidence of PC has been increasing steadily. Therefore, the present study aimed to identify effective markers in the early and advanced stages of PC. The expression levels of complement C3, complement C4b1 and apolipoprotein E (ApoE) in the various stages of PC were assessed by immunohistochemistry, RT-PCR and western blotting. Additionally, the statistical significance of the results was analyzed. The expression levels of complement C3, complement C4b1 and apoE were higher in PC compared with normal pancreatic tissues. No correlations were observed between complement C3 and tumor TNM staging or lymph node metastasis. However, complement C4b1 and apoE were markedly correlated with tumor TNM staging and lymph node metastasis. Complement C3 may be used as a marker for the diagnosis of early-stage PC, while complement C4b1 and apoE are closely correlated with tumor development, reflecting the biological behavior of PC, and thus may be used as diagnostic markers of advanced PC.
publisher	D.A. Spandidos
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742809/
_version_	1612002935099621376

Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer

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