Presence of proNGF-Sortilin Signaling Complex in Nigral Dopamine Neurons and Its Variation in Relation to Aging, Lactacystin and 6-OHDA Insults

Presence of proNGF-Sortilin Signaling Complex in Nigral Dopamine Neurons and Its Variation in Relation to Aging, Lactacystin and 6-OHDA Insults

Growing evidence has shown that proNGF-p75NTR-sortilin signaling might be a crucial factor in neurodegeneration, but it remains unclear if it may function in nigral neurons under aging and disease. The purpose of this study is to examine and quantify proNGF and sortilin expression in the substantia...

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Bibliographic Details
Main Authors: Xia, Yi, Chen, Bei-Yu, Sun, Xiao-Long, Duan, Li, Gao, Guo-Dong, Wang, Jing-Jie, Yung, Ken Kam-Lin, Chen, Liang-Wei
Format: Online
Language:English
Published: Molecular Diversity Preservation International (MDPI) 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742233/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742233/

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