Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats

Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression in the rostral ventrolateral medulla (RVLM). Baroreflex sensitivity and c-Fos protein expression in t...

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Main Authors:	Lan, Yan, Yang, Yan-Zhao, Jiang, Xian, Li, Li-Wei, Jin, Guang-Shi, Kim, Min Sun, Park, Byung Rim, Jin, Yuan-Zhe
Format:	Online
Language:	English
Published:	The Korean Physiological Society and The Korean Society of Pharmacology 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741494/

id	pubmed-3741494
recordtype	oai_dc
spelling	pubmed-37414942013-08-14 Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats Lan, Yan Yang, Yan-Zhao Jiang, Xian Li, Li-Wei Jin, Guang-Shi Kim, Min Sun Park, Byung Rim Jin, Yuan-Zhe Original Article Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression in the rostral ventrolateral medulla (RVLM). Baroreflex sensitivity and c-Fos protein expression in the RVLM were measured in conscious rats that had undergone bilateral labyrinthectomy (BL) and/or baroreceptor unloading. BL attenuated baroreflex sensitivity during intravenous infusion of sodium nitroprusside (SNP), but did not significantly affect the sensitivity following infusion of phenylephrine (PE). Baroreflex sensitivity became positive following sinoaortic denervation (SAD) during infusion of PE and attenuated sensitivity during infusion of SNP. Baroreflex sensitivity also became positive following double ablation (BL+SAD) during infusion of PE, and attenuated sensitivity during infusion of SNP. c-Fos protein expression increased significantly in the RVLM in the sham group after SNP administration. However, the BL, SAD, and SAD+BL groups showed significant decreases in c-Fos protein expression compared with that in the sham group. The SAD group showed more reduced c-Fos protein expression than that in the BL group, and the SAD+BL group showed less expression than that in the SAD group. These results suggest that the vestibular system cooperates with baroreceptors to maintain arterial pressure during hypotension but that baroreceptors regulate arterial pressure during both hypotension and hypertension. Additionally, afferent signals for maintaining blood pressure from the vestibular end organs and the baroreceptors may be integrated in the RVLM. The Korean Physiological Society and The Korean Society of Pharmacology 2013-08 2013-07-30 /pmc/articles/PMC3741494/ /pubmed/23946697 http://dx.doi.org/10.4196/kjpp.2013.17.4.367 Text en Copyright © 2013 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lan, Yan Yang, Yan-Zhao Jiang, Xian Li, Li-Wei Jin, Guang-Shi Kim, Min Sun Park, Byung Rim Jin, Yuan-Zhe
spellingShingle	Lan, Yan Yang, Yan-Zhao Jiang, Xian Li, Li-Wei Jin, Guang-Shi Kim, Min Sun Park, Byung Rim Jin, Yuan-Zhe Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
author_facet	Lan, Yan Yang, Yan-Zhao Jiang, Xian Li, Li-Wei Jin, Guang-Shi Kim, Min Sun Park, Byung Rim Jin, Yuan-Zhe
author_sort	Lan, Yan
title	Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
title_short	Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
title_full	Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
title_fullStr	Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
title_full_unstemmed	Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats
title_sort	additive role of the vestibular end organ and baroreceptors on the regulation of blood pressure in rats
description	Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression in the rostral ventrolateral medulla (RVLM). Baroreflex sensitivity and c-Fos protein expression in the RVLM were measured in conscious rats that had undergone bilateral labyrinthectomy (BL) and/or baroreceptor unloading. BL attenuated baroreflex sensitivity during intravenous infusion of sodium nitroprusside (SNP), but did not significantly affect the sensitivity following infusion of phenylephrine (PE). Baroreflex sensitivity became positive following sinoaortic denervation (SAD) during infusion of PE and attenuated sensitivity during infusion of SNP. Baroreflex sensitivity also became positive following double ablation (BL+SAD) during infusion of PE, and attenuated sensitivity during infusion of SNP. c-Fos protein expression increased significantly in the RVLM in the sham group after SNP administration. However, the BL, SAD, and SAD+BL groups showed significant decreases in c-Fos protein expression compared with that in the sham group. The SAD group showed more reduced c-Fos protein expression than that in the BL group, and the SAD+BL group showed less expression than that in the SAD group. These results suggest that the vestibular system cooperates with baroreceptors to maintain arterial pressure during hypotension but that baroreceptors regulate arterial pressure during both hypotension and hypertension. Additionally, afferent signals for maintaining blood pressure from the vestibular end organs and the baroreceptors may be integrated in the RVLM.
publisher	The Korean Physiological Society and The Korean Society of Pharmacology
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741494/
_version_	1612002545227530240

Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats

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