Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review

Hilar cholangiocarcinoma (HC) is a rare tumor that causes devastating disease. In the late stages, this carcinoma primarily invades the portal vein and metastasizes to the hepatic lobes; it is associated with a poor prognosis. HC is diagnosed by its clinical manifestation and results of imaging tech...

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Main Authors:	Zhimin, Geng, Noor, Hidayatullah, Jian-Bo, Zheng, Lin, Wang, Jha, Rajiv Kumar
Format:	Online
Language:	English
Published:	International Scientific Literature, Inc. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739601/

id	pubmed-3739601
recordtype	oai_dc
spelling	pubmed-37396012013-08-12 Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review Zhimin, Geng Noor, Hidayatullah Jian-Bo, Zheng Lin, Wang Jha, Rajiv Kumar Review Articles Hilar cholangiocarcinoma (HC) is a rare tumor that causes devastating disease. In the late stages, this carcinoma primarily invades the portal vein and metastasizes to the hepatic lobes; it is associated with a poor prognosis. HC is diagnosed by its clinical manifestation and results of imaging techniques such as ultrasound, computed tomography, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography. Preoperative hepatic bile drainage can improve symptoms associated with insufficient liver and kidney function, coagulopathy, and jaundice. Surgical margin-negative (R0) resection, including major liver resection, is the most effective and potentially curative treatment for HC. If the tumor is not resected, then liver transplantation with adjuvant management can improve survival. We conducted a systematic review of developments in imaging studies and major surgical hepatectomy for HC with positive outcomes regarding quality of life. International Scientific Literature, Inc. 2013-08-07 /pmc/articles/PMC3739601/ /pubmed/23921971 http://dx.doi.org/10.12659/MSM.889379 Text en © Med Sci Monit, 2013 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhimin, Geng Noor, Hidayatullah Jian-Bo, Zheng Lin, Wang Jha, Rajiv Kumar
spellingShingle	Zhimin, Geng Noor, Hidayatullah Jian-Bo, Zheng Lin, Wang Jha, Rajiv Kumar Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
author_facet	Zhimin, Geng Noor, Hidayatullah Jian-Bo, Zheng Lin, Wang Jha, Rajiv Kumar
author_sort	Zhimin, Geng
title	Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
title_short	Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
title_full	Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
title_fullStr	Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
title_full_unstemmed	Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
title_sort	advances in diagnosis and treatment of hilar cholangiocarcinoma – a review
description	Hilar cholangiocarcinoma (HC) is a rare tumor that causes devastating disease. In the late stages, this carcinoma primarily invades the portal vein and metastasizes to the hepatic lobes; it is associated with a poor prognosis. HC is diagnosed by its clinical manifestation and results of imaging techniques such as ultrasound, computed tomography, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography. Preoperative hepatic bile drainage can improve symptoms associated with insufficient liver and kidney function, coagulopathy, and jaundice. Surgical margin-negative (R0) resection, including major liver resection, is the most effective and potentially curative treatment for HC. If the tumor is not resected, then liver transplantation with adjuvant management can improve survival. We conducted a systematic review of developments in imaging studies and major surgical hepatectomy for HC with positive outcomes regarding quality of life.
publisher	International Scientific Literature, Inc.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739601/
_version_	1612002102860578816

Advances in diagnosis and treatment of hilar cholangiocarcinoma – a review

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