SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

Enteric bacterial pathogens such as enterohemorrhagic E. coli (EHEC) and Salmonella Typhimurium target the intestinal epithelial cells (IEC) lining the mammalian gastrointestinal tract. Despite expressing innate Toll-like receptors (TLRs), IEC are innately hypo-responsive to most bacterial products....

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Bibliographic Details
Main Authors: Sham, Ho Pan, Yu, Emily Yi Shan, Gulen, Muhammet F., Bhinder, Ganive, Stahl, Martin, Chan, Justin M., Brewster, Lara, Morampudi, Vijay, Gibson, Deanna L., Hughes, Michael R., McNagny, Kelly M., Li, Xiaoxia, Vallance, Bruce A.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738496/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738496/

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