Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Ubiquitination by HECT E3 enzymes regulates myriad processes, including tumor suppression, transcription, protein trafficking, and degradation. HECT E3s use a two-step mechanism to ligate ubiquitin to target proteins. The first step is guided by interactions between the catalytic HECT domain and the...

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Bibliographic Details
Main Authors: Kamadurai, Hari B, Qiu, Yu, Deng, Alan, Harrison, Joseph S, MacDonald, Chris, Actis, Marcelo, Rodrigues, Patrick, Miller, Darcie J, Souphron, Judith, Lewis, Steven M, Kurinov, Igor, Fujii, Naoaki, Hammel, Michal, Piper, Robert, Kuhlman, Brian, Schulman, Brenda A
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738095/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738095/

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