Genetic Selection for Constitutively Trimerized Human HSF1 Mutants Identifies a Role for Coiled-Coil Motifs in DNA Binding
Human heat shock transcription factor 1 (HSF1) promotes the expression of stress-responsive genes and is a critical factor for the cellular protective response to proteotoxic and other stresses. In response to stress, HSF1 undergoes a transition from a repressed cytoplasmic monomer to a homotrimer,...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Genetics Society of America
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737171/ |