Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

Quantitative proteomics, lifespan analysis, and biochemical assays were utilized to show that Insulin/IGF-1-mediated longevity in C. elegans is strongly associated with a daf-16 dependent global reduction in protein metabolism.

Bibliographic Details
Main Authors: Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734508/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734508/

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