CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling

CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling

Loss of CCM1/2 leads to destabilization of ICAP-1 and up-regulation of β1 integrin, resulting in the destabilization of intercellular junctions due to increased cell contractility and aberrant extracellular matrix remodeling.

Bibliographic Details
Main Authors: Faurobert, Eva, Rome, Claire, Lisowska, Justyna, Manet-Dupé, Sandra, Boulday, Gwénola, Malbouyres, Marilyne, Balland, Martial, Bouin, Anne-Pascale, Kéramidas, Michelle, Bouvard, Daniel, Coll, Jean-Luc, Ruggiero, Florence, Tournier-Lasserve, Elisabeth, Albiges-Rizo, Corinne
Format: Online
Language:English
Published: The Rockefeller University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734079/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734079/

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