Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms☆

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms☆

•Acute application of apo(a) to smooth muscle cells induced chemorepulsion.•Chronic application (>24 h) induced stress fibre formation and cell spreading.•Effects of apo(a) were mediated by integrin αVβ3, tyrosine kinases and RhoA/ROCK.•Apo(a) impaired SMC motility which potentially contributes t...

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Bibliographic Details
Main Authors: Riches, Kirsten, Franklin, Larissa, Maqbool, Azhar, Peckham, Michelle, Adams, Matthew, Bond, Jacquelyn, Warburton, Philip, Feric, Nicole T., Koschinsky, Marlys L., O’Regan, David J., Ball, Stephen G., Turner, Neil A., Porter, Karen E.
Format: Online
Language:English
Published: Elsevier 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731554/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731554/

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