Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse

Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse

Currently, the treatment of pediatric high-grade osteosarcomas systematically includes one topoisomerase IIα inhibitor. This chemotherapy is usually adapted to the response to the neo-adjuvant therapy after surgery. The current and unique marker of chemoresponsiveness is the percentage of viable res...

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Bibliographic Details
Main Authors: Nguyen, Aurelia, Lasthaus, Christelle, Guerin, Eric, Marcellin, Luc, Pencreach, Erwan, Gaub, Marie-Pierre, Guenot, Dominique, Entz-Werle, Natacha
Format: Online
Language:English
Published: MDPI 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730327/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730327/

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