DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation

Formation of primed single-stranded DNA at stalled replication forks triggers activation of the replication checkpoint signalling cascade resulting in the ATR-mediated phosphorylation of the Chk1 protein kinase, thus preventing genomic instability. By using siRNA-mediated depletion in human cells an...

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Bibliographic Details
Main Authors: Bétous, Rémy, Pillaire, Marie-Jeanne, Pierini, Laura, van der Laan, Siem, Recolin, Bénédicte, Ohl-Séguy, Emma, Guo, Caixia, Niimi, Naoko, Grúz, Petr, Nohmi, Takehiko, Friedberg, Errol, Cazaux, Christophe, Maiorano, Domenico, Hoffmann, Jean-Sébastien
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730229/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730229/

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