A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma

A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma

Despite advances in understanding cancer at the molecular level, timely and effective translation to clinical application of novel therapeutics in human cancer patients is lacking. Cancer drug failure is often a result of toxicity or inefficacy not predicted by preclinical models, emphasizing the ne...

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Main Author: Wypij, Jackie M.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730145/
id pubmed-3730145
recordtype oai_dc
spelling pubmed-37301452013-08-22 A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma Wypij, Jackie M. Review Article Despite advances in understanding cancer at the molecular level, timely and effective translation to clinical application of novel therapeutics in human cancer patients is lacking. Cancer drug failure is often a result of toxicity or inefficacy not predicted by preclinical models, emphasizing the need for alternative animal tumor models with improved biologic relevancy. Companion animals (dogs and cats) provide an opportunity to capitalize on an underutilized and biologically relevant translational research model which allows spontaneous disease modeling of human cancer. Head and neck squamous cell carcinoma (HNSCC) is a common cancer with a poor prognosis and limited clinical advancements in recent years. One potential novel spontaneous animal tumor model is feline oral squamous cell carcinoma (FOSCC). FOSCC and HNSCC share similar etiopathogenesis (tobacco and papillomavirus exposure) and molecular markers (EGFR, VEGF, and p53). Both human and feline SCCs share similar tumor biology, clinical outcome, treatment, and prognosis. Future clinical trials utilizing FOSCC as a tumor model may facilitate translation of preclinical cancer research for human cancer patients. Hindawi Publishing Corporation 2013 2013-07-16 /pmc/articles/PMC3730145/ /pubmed/23970998 http://dx.doi.org/10.1155/2013/502197 Text en Copyright © 2013 Jackie M. Wypij. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Wypij, Jackie M.
spellingShingle Wypij, Jackie M.
A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma
author_facet Wypij, Jackie M.
author_sort Wypij, Jackie M.
title A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma
title_short A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma
title_full A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma
title_fullStr A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma
title_full_unstemmed A Naturally Occurring Feline Model of Head and Neck Squamous Cell Carcinoma
title_sort naturally occurring feline model of head and neck squamous cell carcinoma
description Despite advances in understanding cancer at the molecular level, timely and effective translation to clinical application of novel therapeutics in human cancer patients is lacking. Cancer drug failure is often a result of toxicity or inefficacy not predicted by preclinical models, emphasizing the need for alternative animal tumor models with improved biologic relevancy. Companion animals (dogs and cats) provide an opportunity to capitalize on an underutilized and biologically relevant translational research model which allows spontaneous disease modeling of human cancer. Head and neck squamous cell carcinoma (HNSCC) is a common cancer with a poor prognosis and limited clinical advancements in recent years. One potential novel spontaneous animal tumor model is feline oral squamous cell carcinoma (FOSCC). FOSCC and HNSCC share similar etiopathogenesis (tobacco and papillomavirus exposure) and molecular markers (EGFR, VEGF, and p53). Both human and feline SCCs share similar tumor biology, clinical outcome, treatment, and prognosis. Future clinical trials utilizing FOSCC as a tumor model may facilitate translation of preclinical cancer research for human cancer patients.
publisher Hindawi Publishing Corporation
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730145/
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