Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger glucocorticoid response element-regulated gene expressi...

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Bibliographic Details
Main Authors: Beck, Ilse M., Drebert, Zuzanna J., Hoya-Arias, Ruben, Bahar, Ali A., Devos, Michael, Clarisse, Dorien, Desmet, Sofie, Bougarne, Nadia, Ruttens, Bart, Gossye, Valerie, Denecker, Geertrui, Lievens, Sam, Bracke, Marc, Tavernier, Jan, Declercq, Wim, Gevaert, Kris, Berghe, Wim Vanden, Haegeman, Guy, De Bosscher, Karolien
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728325/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728325/

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