Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China

Recently, a highly dangerous bird flu has infected over 130 patients in China, and the outbreak was attributed to a novel avian-origin H7N9 virus. Here, we performed a systematic analysis of the virus. We clarified the controversial viewpoint on neuraminidase (NA) origin and confirmed it was reassor...

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Main Authors:	Wang, Yongbo, Dai, Zhangyan, Cheng, Han, Liu, Zexian, Pan, Zhicheng, Deng, Wankun, Gao, Tianshun, Li, Xiaotong, Yao, Yuangen, Ren, Jian, Xue, Yu
Format:	Online
Language:	English
Published:	Nature Publishing Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727058/

id	pubmed-3727058
recordtype	oai_dc
spelling	pubmed-37270582013-07-30 Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China Wang, Yongbo Dai, Zhangyan Cheng, Han Liu, Zexian Pan, Zhicheng Deng, Wankun Gao, Tianshun Li, Xiaotong Yao, Yuangen Ren, Jian Xue, Yu Article Recently, a highly dangerous bird flu has infected over 130 patients in China, and the outbreak was attributed to a novel avian-origin H7N9 virus. Here, we performed a systematic analysis of the virus. We clarified the controversial viewpoint on neuraminidase (NA) origin and confirmed it was reassorted from Korean wild birds with higher confidence, whereas common ancestors of pathogenic H7N9 genes existed only one or two years ago. Further analysis of NA sequences suggested that most variations are not drug resistant and current drugs are still effective for the therapy. We also identified a potentially optimal 9-mer epitope, which can be helpful for vaccine development. The interaction of hemagglutinin (HA) and human receptor analog was confirmed by structural modeling, while NA might influence cellular processes through a PDZ-binding motif. A simplified virus infection model was proposed. Taken together, our studies provide a better understanding of the newly reassorted H7N9 viruses. Nature Publishing Group 2013-07-30 /pmc/articles/PMC3727058/ /pubmed/23897131 http://dx.doi.org/10.1038/srep02318 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Yongbo Dai, Zhangyan Cheng, Han Liu, Zexian Pan, Zhicheng Deng, Wankun Gao, Tianshun Li, Xiaotong Yao, Yuangen Ren, Jian Xue, Yu
spellingShingle	Wang, Yongbo Dai, Zhangyan Cheng, Han Liu, Zexian Pan, Zhicheng Deng, Wankun Gao, Tianshun Li, Xiaotong Yao, Yuangen Ren, Jian Xue, Yu Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
author_facet	Wang, Yongbo Dai, Zhangyan Cheng, Han Liu, Zexian Pan, Zhicheng Deng, Wankun Gao, Tianshun Li, Xiaotong Yao, Yuangen Ren, Jian Xue, Yu
author_sort	Wang, Yongbo
title	Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
title_short	Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
title_full	Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
title_fullStr	Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
title_full_unstemmed	Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China
title_sort	towards a better understanding of the novel avian-origin h7n9 influenza a virus in china
description	Recently, a highly dangerous bird flu has infected over 130 patients in China, and the outbreak was attributed to a novel avian-origin H7N9 virus. Here, we performed a systematic analysis of the virus. We clarified the controversial viewpoint on neuraminidase (NA) origin and confirmed it was reassorted from Korean wild birds with higher confidence, whereas common ancestors of pathogenic H7N9 genes existed only one or two years ago. Further analysis of NA sequences suggested that most variations are not drug resistant and current drugs are still effective for the therapy. We also identified a potentially optimal 9-mer epitope, which can be helpful for vaccine development. The interaction of hemagglutinin (HA) and human receptor analog was confirmed by structural modeling, while NA might influence cellular processes through a PDZ-binding motif. A simplified virus infection model was proposed. Taken together, our studies provide a better understanding of the newly reassorted H7N9 viruses.
publisher	Nature Publishing Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727058/
_version_	1611999014500171776

Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China

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