Cholinergic modulation of hippocampal network function
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear...
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Frontiers Media S.A.
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726829/ |
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pubmed-37268292013-08-01 Cholinergic modulation of hippocampal network function Teles-Grilo Ruivo, Leonor M. Mellor, Jack R. Neuroscience Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviors. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organization of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity, and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus. Frontiers Media S.A. 2013-07-30 /pmc/articles/PMC3726829/ /pubmed/23908628 http://dx.doi.org/10.3389/fnsyn.2013.00002 Text en Copyright © 2013 Teles-Grilo Ruivo and Mellor. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Teles-Grilo Ruivo, Leonor M. Mellor, Jack R. |
| spellingShingle |
Teles-Grilo Ruivo, Leonor M. Mellor, Jack R. Cholinergic modulation of hippocampal network function |
| author_facet |
Teles-Grilo Ruivo, Leonor M. Mellor, Jack R. |
| author_sort |
Teles-Grilo Ruivo, Leonor M. |
| title |
Cholinergic modulation of hippocampal network function |
| title_short |
Cholinergic modulation of hippocampal network function |
| title_full |
Cholinergic modulation of hippocampal network function |
| title_fullStr |
Cholinergic modulation of hippocampal network function |
| title_full_unstemmed |
Cholinergic modulation of hippocampal network function |
| title_sort |
cholinergic modulation of hippocampal network function |
| description |
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviors. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organization of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity, and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726829/ |
| _version_ |
1611998945163083776 |