Optimizing Nasal Potential Difference Analysis for CFTR Modulator Development: Assessment of Ivacaftor in CF Subjects with the G551D-CFTR Mutation

Optimizing Nasal Potential Difference Analysis for CFTR Modulator Development: Assessment of Ivacaftor in CF Subjects with the G551D-CFTR Mutation

Nasal potential difference (NPD) is used as a biomarker of the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) activity. We evaluated methods to detect changes in chloride and sodium transport by NPD based on a secondary analysis of a Phase II CFTR-mod...

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Bibliographic Details
Main Authors: Rowe, Steven M., Liu, Bo, Hill, Aubrey, Hathorne, Heather, Cohen, Morty, Beamer, John R., Accurso, Frank J., Dong, Qunming, Ordoñez, Claudia L., Stone, Anne J., Olson, Eric R., Clancy, John P.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724869/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724869/

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