Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

This study examines the regulating effect of Sonic Hedgehog (Shh) on the permeability of the blood-brain barrier (BBB) in cerebral ischemia. By employing permanent middle cerebral artery occlusion (pMCAO) model, we find that Shh significantly decreases brain edema and preserves BBB permeability. Mor...

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Bibliographic Details
Main Authors: Xia, Yuan-peng, He, Quan-wei, Li, Ya-nan, Chen, Sheng-cai, Huang, Ming, Wang, Yong, Gao, Yuan, Huang, Yan, Wang, Meng-die, Mao, Ling, Hu, Bo
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720889/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720889/

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