Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach

The question of how affective processing is organized in the brain is still a matter of controversial discussions. Based on previous initial evidence, several suggestions have been put forward regarding the involved brain areas: (a) right-lateralized dominance in emotional processing, (b) hemispheri...

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Main Authors:	Rohr, Christiane S., Okon-Singer, Hadas, Craddock, R. Cameron, Villringer, Arno, Margulies, Daniel S.
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720669/

id	pubmed-3720669
recordtype	oai_dc
spelling	pubmed-37206692013-08-09 Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach Rohr, Christiane S. Okon-Singer, Hadas Craddock, R. Cameron Villringer, Arno Margulies, Daniel S. Research Article The question of how affective processing is organized in the brain is still a matter of controversial discussions. Based on previous initial evidence, several suggestions have been put forward regarding the involved brain areas: (a) right-lateralized dominance in emotional processing, (b) hemispheric dominance according to positive or negative valence, (c) one network for all emotional processing and (d) region-specific discrete emotion matching. We examined these hypotheses by investigating intrinsic functional connectivity patterns that covary with results of the Positive and Negative Affective Schedule (PANAS) from 65 participants. This approach has the advantage of being able to test connectivity rather than activation, and not requiring a potentially confounding task. Voxelwise functional connectivity from 200 regions-of-interest covering the whole brain was assessed. Positive and negative affect covaried with functional connectivity involving a shared set of regions, including the medial prefrontal cortex, the anterior cingulate, the visual cortex and the cerebellum. In addition, each affective domain had unique connectivity patterns, and the lateralization index showed a right hemispheric dominance for negative affect. Therefore, our results suggest a predominantly right-hemispheric network with affect-specific elements as the underlying organization of emotional processes. Public Library of Science 2013-07-23 /pmc/articles/PMC3720669/ /pubmed/23935850 http://dx.doi.org/10.1371/journal.pone.0068015 Text en © 2013 Rohr et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Rohr, Christiane S. Okon-Singer, Hadas Craddock, R. Cameron Villringer, Arno Margulies, Daniel S.
spellingShingle	Rohr, Christiane S. Okon-Singer, Hadas Craddock, R. Cameron Villringer, Arno Margulies, Daniel S. Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
author_facet	Rohr, Christiane S. Okon-Singer, Hadas Craddock, R. Cameron Villringer, Arno Margulies, Daniel S.
author_sort	Rohr, Christiane S.
title	Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
title_short	Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
title_full	Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
title_fullStr	Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
title_full_unstemmed	Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
title_sort	affect and the brain's functional organization: a resting-state connectivity approach
description	The question of how affective processing is organized in the brain is still a matter of controversial discussions. Based on previous initial evidence, several suggestions have been put forward regarding the involved brain areas: (a) right-lateralized dominance in emotional processing, (b) hemispheric dominance according to positive or negative valence, (c) one network for all emotional processing and (d) region-specific discrete emotion matching. We examined these hypotheses by investigating intrinsic functional connectivity patterns that covary with results of the Positive and Negative Affective Schedule (PANAS) from 65 participants. This approach has the advantage of being able to test connectivity rather than activation, and not requiring a potentially confounding task. Voxelwise functional connectivity from 200 regions-of-interest covering the whole brain was assessed. Positive and negative affect covaried with functional connectivity involving a shared set of regions, including the medial prefrontal cortex, the anterior cingulate, the visual cortex and the cerebellum. In addition, each affective domain had unique connectivity patterns, and the lateralization index showed a right hemispheric dominance for negative affect. Therefore, our results suggest a predominantly right-hemispheric network with affect-specific elements as the underlying organization of emotional processes.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720669/
_version_	1611997212080865280

Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach

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