Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms
Constitutively activated signaling molecules are often the primary drivers of malignancy, and are favored targets for therapeutic intervention. However, the effectiveness of targeted inhibition of cell signaling can be blunted by compensatory signaling which generates adaptive resistance mechanisms...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720609/ |