Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury

Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury

Endothelial-myocardial interactions may be critically important for ischemia/reperfusion injury. Tetrahydrobiopterin (BH4) is a required cofactor for nitric oxide (NO) production by endothelial NO synthase (eNOS). Hyperglycemia (HG) leads to significant increases in oxidative stress, oxidizing BH4 t...

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Bibliographic Details
Main Authors: Leucker, Thorsten M., Ge, Zhi-Dong, Procknow, Jesse, Liu, Yanan, Shi, Yang, Bienengraeber, Martin, Warltier, David C., Kersten, Judy R.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718730/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718730/

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