Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese
Obesity and insulin resistance are associated with altered brain glucose metabolism. Here, we studied brain glucose metabolism in 22 morbidly obese patients before and 6 months after bariatric surgery. Seven healthy subjects served as control subjects. Brain glucose metabolism was measured twice per...
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| Format: | Online |
| Language: | English |
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American Diabetes Association
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717871/ |
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pubmed-3717871 |
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oai_dc |
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pubmed-37178712014-08-01 Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese Tuulari, Jetro J. Karlsson, Henry K. Hirvonen, Jussi Hannukainen, Jarna C. Bucci, Marco Helmiö, Mika Ovaska, Jari Soinio, Minna Salminen, Paulina Savisto, Nina Nummenmaa, Lauri Nuutila, Pirjo Original Research Obesity and insulin resistance are associated with altered brain glucose metabolism. Here, we studied brain glucose metabolism in 22 morbidly obese patients before and 6 months after bariatric surgery. Seven healthy subjects served as control subjects. Brain glucose metabolism was measured twice per imaging session: with and without insulin stimulation (hyperinsulinemic-euglycemic clamp) using [18F]fluorodeoxyglucose scanning. We found that during fasting, brain glucose metabolism was not different between groups. However, the hyperinsulinemic clamp increased brain glucose metabolism in a widespread manner in the obese but not control subjects, and brain glucose metabolism was significantly higher during clamp in obese than in control subjects. After follow-up, 6 months postoperatively, the increase in glucose metabolism was no longer observed, and this attenuation was coupled with improved peripheral insulin sensitivity after weight loss. We conclude that obesity is associated with increased insulin-stimulated glucose metabolism in the brain and that this abnormality can be reversed by bariatric surgery. American Diabetes Association 2013-08 2013-07-17 /pmc/articles/PMC3717871/ /pubmed/23493575 http://dx.doi.org/10.2337/db12-1460 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Tuulari, Jetro J. Karlsson, Henry K. Hirvonen, Jussi Hannukainen, Jarna C. Bucci, Marco Helmiö, Mika Ovaska, Jari Soinio, Minna Salminen, Paulina Savisto, Nina Nummenmaa, Lauri Nuutila, Pirjo |
| spellingShingle |
Tuulari, Jetro J. Karlsson, Henry K. Hirvonen, Jussi Hannukainen, Jarna C. Bucci, Marco Helmiö, Mika Ovaska, Jari Soinio, Minna Salminen, Paulina Savisto, Nina Nummenmaa, Lauri Nuutila, Pirjo Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese |
| author_facet |
Tuulari, Jetro J. Karlsson, Henry K. Hirvonen, Jussi Hannukainen, Jarna C. Bucci, Marco Helmiö, Mika Ovaska, Jari Soinio, Minna Salminen, Paulina Savisto, Nina Nummenmaa, Lauri Nuutila, Pirjo |
| author_sort |
Tuulari, Jetro J. |
| title |
Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese |
| title_short |
Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese |
| title_full |
Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese |
| title_fullStr |
Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese |
| title_full_unstemmed |
Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese |
| title_sort |
weight loss after bariatric surgery reverses insulin-induced increases in brain glucose metabolism of the morbidly obese |
| description |
Obesity and insulin resistance are associated with altered brain glucose metabolism. Here, we studied brain glucose metabolism in 22 morbidly obese patients before and 6 months after bariatric surgery. Seven healthy subjects served as control subjects. Brain glucose metabolism was measured twice per imaging session: with and without insulin stimulation (hyperinsulinemic-euglycemic clamp) using [18F]fluorodeoxyglucose scanning. We found that during fasting, brain glucose metabolism was not different between groups. However, the hyperinsulinemic clamp increased brain glucose metabolism in a widespread manner in the obese but not control subjects, and brain glucose metabolism was significantly higher during clamp in obese than in control subjects. After follow-up, 6 months postoperatively, the increase in glucose metabolism was no longer observed, and this attenuation was coupled with improved peripheral insulin sensitivity after weight loss. We conclude that obesity is associated with increased insulin-stimulated glucose metabolism in the brain and that this abnormality can be reversed by bariatric surgery. |
| publisher |
American Diabetes Association |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717871/ |
| _version_ |
1611996643091021824 |