Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer

Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer

Genetic alterations activating K-RAS and PI3K/AKT signaling are also known to induce the activity of mTOR kinase through TORC1 and TORC2 complexes in human pancreatic ductal adenocarcinoma (PDAC). Here, we determined the effects of the dual PI3K and mTOR inhibitor, NVP-BEZ235 (BEZ235), and the pan-h...

Full description

Bibliographic Details
Main Authors: Venkannagari, Sreedhar, Fiskus, Warren, Peth, Karissa, Atadja, Peter, Hidalgo, Manuel, Maitra, Anirban, Bhalla, Kapil N.
Format: Online
Language:English
Published: Impact Journals LLC 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717802/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717802/

Similar Items