Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment
T cells in tumors—the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in patients w...
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| Format: | Online |
| Language: | English |
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Springer Netherlands
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717059/ |
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pubmed-3717059 |
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pubmed-37170592013-07-23 Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment Hadrup, Sine Donia, Marco thor Straten, Per Original Paper T cells in tumors—the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in patients with colo-rectal cancer (CRC), and also for others solid cancers. These data goes hand in hand with studies of clonality of TIL showing the T cells among TIL are expanded clonally, and also that tumor specific T cells of CD4 as well as CD8 type are enriched at the tumor site. The tumor microenvironment is hostile to T cell function e.g., due to expression of enzymes that depletes the amino acids tryptophan and arginine, high concentration of tumor secreted lactate, and presence innate cells or regulatory T cells both with suppressive activity. Analyses of the specificity of TILs in melanoma demonstrate that quite few known antigens are in fact recognized by these cultures underscoring patient unique and/or mutated antigens may represent important target for recognition. Springer Netherlands 2012-12-16 /pmc/articles/PMC3717059/ /pubmed/23242673 http://dx.doi.org/10.1007/s12307-012-0127-6 Text en © The Author(s) 2012 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hadrup, Sine Donia, Marco thor Straten, Per |
| spellingShingle |
Hadrup, Sine Donia, Marco thor Straten, Per Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment |
| author_facet |
Hadrup, Sine Donia, Marco thor Straten, Per |
| author_sort |
Hadrup, Sine |
| title |
Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment |
| title_short |
Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment |
| title_full |
Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment |
| title_fullStr |
Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment |
| title_full_unstemmed |
Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment |
| title_sort |
effector cd4 and cd8 t cells and their role in the tumor microenvironment |
| description |
T cells in tumors—the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in patients with colo-rectal cancer (CRC), and also for others solid cancers. These data goes hand in hand with studies of clonality of TIL showing the T cells among TIL are expanded clonally, and also that tumor specific T cells of CD4 as well as CD8 type are enriched at the tumor site. The tumor microenvironment is hostile to T cell function e.g., due to expression of enzymes that depletes the amino acids tryptophan and arginine, high concentration of tumor secreted lactate, and presence innate cells or regulatory T cells both with suppressive activity. Analyses of the specificity of TILs in melanoma demonstrate that quite few known antigens are in fact recognized by these cultures underscoring patient unique and/or mutated antigens may represent important target for recognition. |
| publisher |
Springer Netherlands |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717059/ |
| _version_ |
1611996420316856320 |