Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear

Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear

Sleep deprivation immediately following an aversive event reduces fear by preventing memory consolidation during homeostatic sleep. This suggests that acute insomnia might act prophylactically against the development of posttraumatic stress disorder (PTSD) even though it is also a possible risk fact...

Full description

Bibliographic Details
Main Authors: Kuriyama, Kenichi, Honma, Motoyasu, Yoshiike, Takuya, Kim, Yoshiharu
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714646/
id pubmed-3714646
recordtype oai_dc
spelling pubmed-37146462013-07-18 Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear Kuriyama, Kenichi Honma, Motoyasu Yoshiike, Takuya Kim, Yoshiharu Article Sleep deprivation immediately following an aversive event reduces fear by preventing memory consolidation during homeostatic sleep. This suggests that acute insomnia might act prophylactically against the development of posttraumatic stress disorder (PTSD) even though it is also a possible risk factor for PTSD. We examined total sleep deprivation and memory suppression to evaluate the effects of these interventions on subsequent aversive memory formation and fear conditioning. Active suppression of aversive memory impaired retention of event memory. However, although the remembered fear was more reduced in sleep-deprived than sleep-control subjects, suppressed fear increased, and seemed to abandon the sleep-dependent plasticity of fear. Active memory suppression, which provides a psychological model for Freud's ego defense mechanism, enhances fear and casts doubt on the potential of acute insomnia as a prophylactic measure against PTSD. Our findings bring into question the role of sleep in aversive-memory consolidation in clinical PTSD pathophysiology. Nature Publishing Group 2013-07-18 /pmc/articles/PMC3714646/ /pubmed/23863955 http://dx.doi.org/10.1038/srep02227 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Kuriyama, Kenichi
Honma, Motoyasu
Yoshiike, Takuya
Kim, Yoshiharu
spellingShingle Kuriyama, Kenichi
Honma, Motoyasu
Yoshiike, Takuya
Kim, Yoshiharu
Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
author_facet Kuriyama, Kenichi
Honma, Motoyasu
Yoshiike, Takuya
Kim, Yoshiharu
author_sort Kuriyama, Kenichi
title Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
title_short Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
title_full Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
title_fullStr Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
title_full_unstemmed Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
title_sort memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear
description Sleep deprivation immediately following an aversive event reduces fear by preventing memory consolidation during homeostatic sleep. This suggests that acute insomnia might act prophylactically against the development of posttraumatic stress disorder (PTSD) even though it is also a possible risk factor for PTSD. We examined total sleep deprivation and memory suppression to evaluate the effects of these interventions on subsequent aversive memory formation and fear conditioning. Active suppression of aversive memory impaired retention of event memory. However, although the remembered fear was more reduced in sleep-deprived than sleep-control subjects, suppressed fear increased, and seemed to abandon the sleep-dependent plasticity of fear. Active memory suppression, which provides a psychological model for Freud's ego defense mechanism, enhances fear and casts doubt on the potential of acute insomnia as a prophylactic measure against PTSD. Our findings bring into question the role of sleep in aversive-memory consolidation in clinical PTSD pathophysiology.
publisher Nature Publishing Group
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714646/
_version_ 1611995806572740608

Similar Items