Efemp1 and p27Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models

Efemp1 and p27Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models

Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease with a poor prognosis and targeted therapies have failed in the clinic so far. Several evidences point to the phosphatidylinositol 3-kinase (PI3K)-mTOR pathway as a promising signaling node for targeted therapeutic intervention. Marker...

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Bibliographic Details
Main Authors: Diersch, Sandra, Patrick, Wenzel, Szameitat, Melanie, Eser, Philipp, Paul, Mariel C., Seidler, Barbara, Eser, Stefan, Messer, Marlena, Reichert, Maximilian, Pagel, Philipp, Esposito, Irene, Schmid, Roland M., Saur, Dieter, Schneider, Günter
Format: Online
Language:English
Published: Impact Journals LLC 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712573/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712573/

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