DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions

DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions

The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds...

Full description

Bibliographic Details
Main Authors: Komatsu, Tetsuro, Sekiya, Takeshi, Nagata, Kyosuke
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711053/
id pubmed-3711053
recordtype oai_dc
spelling pubmed-37110532013-07-15 DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions Komatsu, Tetsuro Sekiya, Takeshi Nagata, Kyosuke Article The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds to viral chromatin depending on viral DNA replication. These findings depict CTCF as a critical regulator for adenovirus genome functions in late phases of infection. Nature Publishing Group 2013-07-15 /pmc/articles/PMC3711053/ /pubmed/23851926 http://dx.doi.org/10.1038/srep02187 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Komatsu, Tetsuro
Sekiya, Takeshi
Nagata, Kyosuke
spellingShingle Komatsu, Tetsuro
Sekiya, Takeshi
Nagata, Kyosuke
DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
author_facet Komatsu, Tetsuro
Sekiya, Takeshi
Nagata, Kyosuke
author_sort Komatsu, Tetsuro
title DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
title_short DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
title_full DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
title_fullStr DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
title_full_unstemmed DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
title_sort dna replication-dependent binding of ctcf plays a critical role in adenovirus genome functions
description The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds to viral chromatin depending on viral DNA replication. These findings depict CTCF as a critical regulator for adenovirus genome functions in late phases of infection.
publisher Nature Publishing Group
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711053/
_version_ 1611994791704264704

Similar Items