Loss of Vps54 Function Leads to Vesicle Traffic Impairment, Protein Mis-Sorting and Embryonic Lethality

Loss of Vps54 Function Leads to Vesicle Traffic Impairment, Protein Mis-Sorting and Embryonic Lethality

The identification of the mutation causing the phenotype of the amyotrophic lateral sclerosis (ALS) model mouse, wobbler, has linked motor neuron degeneration with retrograde vesicle traffic. The wobbler mutation affects protein stability of Vps54, a ubiquitously expressed vesicle-tethering factor a...

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Bibliographic Details
Main Authors: Karlsson, Páll, Droce, Aida, Moser, Jakob M., Cuhlmann, Simon, Padilla, Carolina Ortiz, Heimann, Peter, Bartsch, Jörg W., Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Schmitt-John, Thomas
Format: Online
Language:English
Published: Molecular Diversity Preservation International (MDPI) 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709709/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709709/

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