Lentiviral miR30-based RNA Interference against Heparanase Suppresses Melanoma Metastasis with Lower Liver and Lung Toxicity
Aim: To construct short hairpin RNAs (shRNAs) and miR30-based shRNAs against heparanase (HPSE) to compare their safety and their effects on HPSE down-modulation in vitro and in vivo to develop a more ideal therapeutic RNA interference (RNAi) vector targeting HPSE.
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708037/ |