“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond b...
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| Format: | Online |
| Language: | English |
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MDPI
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707169/ |
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pubmed-3707169 |
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pubmed-37071692013-07-10 “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin Pelay-Gimeno, Marta Tulla-Puche, Judit Albericio, Fernando Review Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein. MDPI 2013-05-21 /pmc/articles/PMC3707169/ /pubmed/23697952 http://dx.doi.org/10.3390/md11051693 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Pelay-Gimeno, Marta Tulla-Puche, Judit Albericio, Fernando |
| spellingShingle |
Pelay-Gimeno, Marta Tulla-Puche, Judit Albericio, Fernando “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| author_facet |
Pelay-Gimeno, Marta Tulla-Puche, Judit Albericio, Fernando |
| author_sort |
Pelay-Gimeno, Marta |
| title |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_short |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_full |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_fullStr |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_full_unstemmed |
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin |
| title_sort |
“head-to-side-chain” cyclodepsipeptides of marine origin |
| description |
Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein. |
| publisher |
MDPI |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707169/ |
| _version_ |
1611993712765698048 |