Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

The accumulation of aggregated mutant huntingtin (mHtt) inclusion bodies is involved in Huntigton’s disease (HD) progression. Medium sized-spiny neurons (MSNs) in the corpus striatum are highly vulnerable to mHtt aggregate accumulation and degeneration, but the mechanisms and pathways involved remai...

Full description

Bibliographic Details
Main Authors: Proenca, Catia C., Stoehr, Natacha, Bernhard, Mario, Seger, Shanon, Genoud, Christel, Roscic, Ana, Paganetti, Paolo, Liu, Shanming, Murphy, Leon O., Kuhn, Rainer, Bouwmeester, Tewis, Galimberti, Ivan
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704647/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704647/

Similar Items