CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished...

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Main Authors: Bradshaw, Elizabeth M, Chibnik, Lori B, Keenan, Brendan T, Ottoboni, Linda, Raj, Towfique, Tang, Anna, Rosenkrantz, Laura L, Imboywa, Selina, Lee, Michelle, Von Korff, Alina, Morris, Martha C, Evans, Denis A, Johnson, Keith, Sperling, Reisa A, Schneider, Julie A, Bennett, David A, De Jager, Philip L
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/
id pubmed-3703870
recordtype oai_dc
spelling pubmed-37038702014-01-01 CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology Bradshaw, Elizabeth M Chibnik, Lori B Keenan, Brendan T Ottoboni, Linda Raj, Towfique Tang, Anna Rosenkrantz, Laura L Imboywa, Selina Lee, Michelle Von Korff, Alina Morris, Martha C Evans, Denis A Johnson, Keith Sperling, Reisa A Schneider, Julie A Bennett, David A De Jager, Philip L Article In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia. 2013-05-23 2013-07 /pmc/articles/PMC3703870/ /pubmed/23708142 http://dx.doi.org/10.1038/nn.3435 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Bradshaw, Elizabeth M
Chibnik, Lori B
Keenan, Brendan T
Ottoboni, Linda
Raj, Towfique
Tang, Anna
Rosenkrantz, Laura L
Imboywa, Selina
Lee, Michelle
Von Korff, Alina
Morris, Martha C
Evans, Denis A
Johnson, Keith
Sperling, Reisa A
Schneider, Julie A
Bennett, David A
De Jager, Philip L
spellingShingle Bradshaw, Elizabeth M
Chibnik, Lori B
Keenan, Brendan T
Ottoboni, Linda
Raj, Towfique
Tang, Anna
Rosenkrantz, Laura L
Imboywa, Selina
Lee, Michelle
Von Korff, Alina
Morris, Martha C
Evans, Denis A
Johnson, Keith
Sperling, Reisa A
Schneider, Julie A
Bennett, David A
De Jager, Philip L
CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
author_facet Bradshaw, Elizabeth M
Chibnik, Lori B
Keenan, Brendan T
Ottoboni, Linda
Raj, Towfique
Tang, Anna
Rosenkrantz, Laura L
Imboywa, Selina
Lee, Michelle
Von Korff, Alina
Morris, Martha C
Evans, Denis A
Johnson, Keith
Sperling, Reisa A
Schneider, Julie A
Bennett, David A
De Jager, Philip L
author_sort Bradshaw, Elizabeth M
title CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
title_short CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
title_full CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
title_fullStr CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
title_full_unstemmed CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
title_sort cd33 alzheimer’s disease locus: altered monocyte function and amyloid biology
description In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia.
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/
_version_ 1611992563312492544

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