BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector...

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Bibliographic Details
Main Authors: Salcedo, Suzana P., Marchesini, María I., Degos, Clara, Terwagne, Matthieu, Von Bargen, Kristine, Lepidi, Hubert, Herrmann, Claudia K., Santos Lacerda, Thais L., Imbert, Paul R. C., Pierre, Philippe, Alexopoulou, Lena, Letesson, Jean-Jacques, Comerci, Diego J., Gorvel, Jean-Pierre
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703528/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703528/

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