Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK activity has been postulated to be an important int...

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Bibliographic Details
Main Authors: Rex, Karen, Jeffries, Shawn, Brown, Matthew L., Carlson, Timothy, Coxon, Angela, Fajardo, Flordeliza, Frank, Brendon, Gustin, Darin, Kamb, Alexander, Kassner, Paul D., Li, Shyun, Li, Yihong, Morgenstern, Kurt, Plant, Matthew, Quon, Kim, Ruefli-Brasse, Astrid, Schmidt, Joanna, Swearingen, Elissa, Walker, Nigel, Wang, Zhulun, Watson, J. E. Vivienne, Wickramasinghe, Dineli, Wong, Mariwil, Xu, Guifen, Wesche, Holger
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702540/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702540/

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