Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa
There have been considerable advances in the past few years in our understanding of how chronic kidney disease (CKD) predisposes to acute kidney injury (AKI) and vice versa. This review shows, however, that few studies have focused on the elderly or conducted stratified analysis by age. It does appe...
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| Format: | Online |
| Language: | English |
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S. Karger AG
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702017/ |
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pubmed-3702017 |
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oai_dc |
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pubmed-37020172013-07-11 Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa Coca, Steven G. Cho, Kerry C. Hsu, Chi-yuan Paper There have been considerable advances in the past few years in our understanding of how chronic kidney disease (CKD) predisposes to acute kidney injury (AKI) and vice versa. This review shows, however, that few studies have focused on the elderly or conducted stratified analysis by age. It does appear that elderly patients with estimated glomerular filtration rate (eGFR) 45–59 ml/min/1.73 m2 are at higher risk for AKI compared with their counterparts with eGFR >60 ml/min/1.73 m2. This is a similar relationship to that seen in younger patients, although effect size appears smaller. As the incidence of AKI has been increasing over the past several years, the proportion of elderly patients surviving after AKI has also been increasing. Since AKI heightens the risk for the development and acceleration of CKD, this implies significant public health concerns with regard to the absolute number of elderly persons developing incident CKD. S. Karger AG 2011-08 2011-08-10 /pmc/articles/PMC3702017/ /pubmed/21832852 http://dx.doi.org/10.1159/000328023 Text en Copyright © 2011 by S. Karger AG, Basel http://www.karger.com/Authors_Choice This is an open access article distributed under the terms of Karger's Author's Choice™ licensing agreement, adapted from the Creative Commons Attribution Non-Commercial 2.5 license. This license allows authors to re-use their articles for educational and research purposes as long as the author and the journal are fully acknowledged. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Coca, Steven G. Cho, Kerry C. Hsu, Chi-yuan |
| spellingShingle |
Coca, Steven G. Cho, Kerry C. Hsu, Chi-yuan Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa |
| author_facet |
Coca, Steven G. Cho, Kerry C. Hsu, Chi-yuan |
| author_sort |
Coca, Steven G. |
| title |
Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa |
| title_short |
Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa |
| title_full |
Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa |
| title_fullStr |
Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa |
| title_full_unstemmed |
Acute Kidney Injury in the Elderly: Predisposition to Chronic Kidney Disease and Vice Versa |
| title_sort |
acute kidney injury in the elderly: predisposition to chronic kidney disease and vice versa |
| description |
There have been considerable advances in the past few years in our understanding of how chronic kidney disease (CKD) predisposes to acute kidney injury (AKI) and vice versa. This review shows, however, that few studies have focused on the elderly or conducted stratified analysis by age. It does appear that elderly patients with estimated glomerular filtration rate (eGFR) 45–59 ml/min/1.73 m2 are at higher risk for AKI compared with their counterparts with eGFR >60 ml/min/1.73 m2. This is a similar relationship to that seen in younger patients, although effect size appears smaller. As the incidence of AKI has been increasing over the past several years, the proportion of elderly patients surviving after AKI has also been increasing. Since AKI heightens the risk for the development and acceleration of CKD, this implies significant public health concerns with regard to the absolute number of elderly persons developing incident CKD. |
| publisher |
S. Karger AG |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702017/ |
| _version_ |
1611992065894252544 |