Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults and as yet no cure for DM1. Here, we report the potential of manumycin A for a novel DM1 therapeutic reagent. DM1 is caused by expansion of CTG repeat. Mutant transcripts containing expanded CUG repeats lead to aberrant...

Full description

Bibliographic Details
Main Authors: Oana, Kosuke, Oma, Yoko, Suo, Satoshi, Takahashi, Masanori P., Nishino, Ichizo, Takeda, Shin'ichi, Ishiura, Shoichi
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701899/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701899/

Similar Items