Exosome-Bound WD Repeat Protein Monad Inhibits Breast Cancer Cell Invasion by Degrading Amphiregulin mRNA

Exosome-Bound WD Repeat Protein Monad Inhibits Breast Cancer Cell Invasion by Degrading Amphiregulin mRNA

Increased stabilization of mRNA coding for key cancer genes can contribute to invasiveness. This is achieved by down-regulation of exosome cofactors, which bind to 3'-UTR in cancer-related genes. Here, we identified amphiregulin, an EGFR ligand, as a target of WD repeat protein Monad, a compone...

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Bibliographic Details
Main Authors: Saeki, Makio, Egusa, Hiroshi, Kamano, Yuya, Kakihara, Yoshito, Houry, Walid A., Yatani, Hirofumi, Noguchi, Shinzaburo, Kamisaki, Yoshinori
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701000/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701000/

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