Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes

This paper describes a procedure that has been optimized for the determination of lamotrigine by Differential Pulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury coated carbon screen-printed electrodes. Selection of the experimental parameters wa...

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Main Authors:	Domínguez-Renedo, Olga, Calvo, M. Encarnación Burgoa, Arcos-Martínez, M. Julia
Format:	Online
Language:	English
Published:	Molecular Diversity Preservation International (MDPI) 2008
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697170/

id	pubmed-3697170
recordtype	oai_dc
spelling	pubmed-36971702013-07-01 Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes Domínguez-Renedo, Olga Calvo, M. Encarnación Burgoa Arcos-Martínez, M. Julia Article This paper describes a procedure that has been optimized for the determination of lamotrigine by Differential Pulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury coated carbon screen-printed electrodes. Selection of the experimental parameters was made using experimental design methodology. The detection limit found was 5.0 × 10-6 M and 2.0 × 10-6 M for the non modified and Hg modified CSPE, respectively. In terms of reproducibility, the precision of the above mentioned methods was calculated in %RSD values at 9.83% for CSPE and 2.73% for Hg-CSPE. The Hg-coated CSPEs developed in this work were successfully applied in the determination of lamotrigine in pharmaceutical preparations. Molecular Diversity Preservation International (MDPI) 2008-07-15 /pmc/articles/PMC3697170/ /pubmed/27879931 http://dx.doi.org/10.3390/s8074201 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Domínguez-Renedo, Olga Calvo, M. Encarnación Burgoa Arcos-Martínez, M. Julia
spellingShingle	Domínguez-Renedo, Olga Calvo, M. Encarnación Burgoa Arcos-Martínez, M. Julia Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes
author_facet	Domínguez-Renedo, Olga Calvo, M. Encarnación Burgoa Arcos-Martínez, M. Julia
author_sort	Domínguez-Renedo, Olga
title	Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes
title_short	Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes
title_full	Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes
title_fullStr	Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes
title_full_unstemmed	Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes
title_sort	determination of lamotrigine in pharmaceutical preparations by adsorptive stripping voltammetry using screen printed electrodes
description	This paper describes a procedure that has been optimized for the determination of lamotrigine by Differential Pulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury coated carbon screen-printed electrodes. Selection of the experimental parameters was made using experimental design methodology. The detection limit found was 5.0 × 10-6 M and 2.0 × 10-6 M for the non modified and Hg modified CSPE, respectively. In terms of reproducibility, the precision of the above mentioned methods was calculated in %RSD values at 9.83% for CSPE and 2.73% for Hg-CSPE. The Hg-coated CSPEs developed in this work were successfully applied in the determination of lamotrigine in pharmaceutical preparations.
publisher	Molecular Diversity Preservation International (MDPI)
publishDate	2008
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697170/
_version_	1611990676555169792

Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes

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