SPCA2 Regulates Orai1 Trafficking and Store Independent Ca2+ Entry in a Model of Lactation

An unconventional interaction between SPCA2, an isoform of the Golgi secretory pathway Ca2+-ATPase, and the Ca2+ influx channel Orai1, has previously been shown to contribute to elevated Ca2+ influx in breast cancer derived cells. In order to investigate the physiological role of this interaction, w...

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Bibliographic Details
Main Authors: Cross, Brandie M., Hack, Anniesha, Reinhardt, Timothy A., Rao, Rajini
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696057/