Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells
► Basal and calcitriol-induced expression of CYP24A1 is cell line dependent. ► Histone deacetylase and methyltransferase inhibitors increase CYP24A1 expression. ► Cell line specific drug response does not correlate with promoter methylation. ► Drug treatment may activate genes upstream of CYP24A1 an...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Pergamon
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695570/ |